Surgery and Prophylaxis with Susoctocog-Alfa in Acquired Hemophilia: Case Series and Literature Review
نویسندگان
چکیده
Background: Acquired hemophilia A (AHA) is a rare bleeding disease due to autoantibodies directed against clotting factor VIII (FVIII). Treatment of AHA consists inhibitor eradication with immunosuppressive therapy (IST) and prompt control obtained bypassing agents or recombinant porcine FVIII (rpFVIII). The latter has recently been licensed for management acute in AHA. Unlike treatment agents, rpFVIII can be monitored provide successful hemostatic effect avoid overtreatment. Correlation between titers efficacy remains matter debate. Methods: We report three cases which was successfully used an unconventional schedule despite the presence medium–high rpFVIII. modified Nijmegen–Bethesda assay (NBA) dose inhibitors. Result: inhibitors prior exposition susoctocog-alfa, that may suggest cross-reactivity human inhibitors, did not affect hemostasis. Conclusion: In our experience, demonstrates safety using both perioperative outpatient settings. Laboratory measurement during described first time.
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2023
ISSN: ['2077-0383']
DOI: https://doi.org/10.3390/jcm12144590